The development and implementation of drugs is usually a very long process, but today in Russia what is usually done in years is done in a matter of weeks.
picture: Julia Pekalova
An unprecedented number of sanctions were imposed against Russia. Delivery of medicines to our country is still going on, but there are difficulties. For example, with drugs for people with complex diseases, with drugs for the treatment of endocrine diseases, with insulin drugs for diabetics. There is no joke with health, so we must learn to produce as much as possible ourselves. import substitution. Komsomolskaya Pravda studied whether there were any successes in this matter. It turns out there is, and great. The development and implementation of drugs is usually a very long process, but today in Russia what is usually done in years is done in a matter of weeks. We talk about the most interesting developments.
In medicinal preparations, it is important not only what is inside, but also what is outside. It depends on the shell of the tablet whether the drug will begin to be released into gastric and intestinal juice, lymph or plasma. Is the drug delivered exactly to the intended organ of the body. Chemists from Tomsk State University have developed their own chemical compound – a polymer – for the production of shells. Using it, you can direct the active substance of the drug exactly to the target. According to the developers, only Russian raw materials are enough for production, and the polymer itself can become a substitute for imported components.
No more dieting
Russian scientists are on the verge of creating a drug to treat chronic gluten intolerance. People with such diseases, for example, cannot eat bread. Scientists from the Department of Chemistry of Natural Compounds, Faculty of Chemistry, Moscow State University and Research Institute of Physical and Chemical Biology named after AI A. Belozersky.
The disease is very common, 1-2% of people suffer from it. Until now, the only way to keep them healthy is to follow a strict diet, but by limiting yourself to food, you do not get the vitamins and minerals necessary for life. As a result, at least depression.
“Our research team is looking for enzymes that can break down toxic grain proteins and peptides,” says co-author of the study, and lead researcher in the Department of Chemistry of Natural Compounds, Faculty of Chemistry, Moscow State University, Doctor of Chemistry, Professor Irina Filippova. These enzymes are called glutinase. The primary outcome of our work was the discovery of glutenins among the digestive enzymes of insect pests of grain stocks.
They work with RADIUM at TOMSK
Most scientists believe that cancer can be defeated with the help of nuclear medicine. There is a reactor at Tomsk Polytechnic University. They are working with radium on it, looking for analogues to treat oncology. Isotopes can indicate the destruction of affected cells, while not touching healthy tissue. The university received radium 223: this isotope will help to cope with damage to the prostate gland. The only drug containing this analog is currently imported, but by the end of the year, scientists plan to test a domestic drug.
Go with nanoparticles
Scientists from the National Research Technological University “MISiS” have synthesized a new material – nanoscale zinc oxide. It has unique anti-bacterial and anti-carcinogenic properties and at the same time is completely non-toxic.
Their other development (together with the Institute of Clinical and Experimental Lymphology in Novosibirsk) is innovative dressings based on organic polymers and silver nanoparticles. They quickly heal diabetic ulcers and chronic wounds.
– We took two materials as a basis. Chitosan is a well-known carbohydrate polymer derived from chitin crustaceans and has many potential clinical applications due to its antibacterial, anticoagulant, tumorigenic and hemostatic properties. Another substance, kurdlan, is a homopolysaccharide that has a positive effect on the human immune system, antitumor and antimicrobial activity, says study author Elizaveta Permyakova, a researcher in the Laboratory of Inorganic Nanomaterials at NUST MISIS.
By changing the temperature, heating time and concentration of sugars, it is possible to obtain biomaterials of different strength and structures: from bandages to foam. In addition, silver nanoparticles contained in the composition stimulate the immune system, accelerating the healing process.
In the future, NUST MISIS scientists plan, under the 2030 Priority Program, which is implemented under the National Science and Universities Project, to develop a “green” method for the synthesis of nanomaterials for biomedical applications.